Skip to main content
Open Access Publications from the University of California

Macromolecular X-ray structure determination using weak, single-wavelength anomalous data.

Published Web Location
No data is associated with this publication.

We describe a likelihood-based method for determining the substructure of anomalously scattering atoms in macromolecular crystals that allows successful structure determination by single-wavelength anomalous diffraction (SAD) X-ray analysis with weak anomalous signal. With the use of partial models and electron density maps in searches for anomalously scattering atoms, testing of alternative values of parameters and parallelized automated model-building, this method has the potential to extend the applicability of the SAD method in challenging cases.

Item not freely available? Link broken?
Report a problem accessing this item