Hyperpolarization of amino acid derivatives in water for biological applications.
- Author(s): Glöggler, S
- Wagner, S
- Bouchard, L-S
- et al.
Published Web Locationhttps://doi.org/10.1039/c5sc00503e
We report on the successful synthesis and hyperpolarization of N-unprotected α-amino acid ethyl propionate esters and extensively, on an alanine derivative hyperpolarized by PHIP (4.4 ± 1.0% 13C-polarization), meeting required levels for in vivo detection. Using water as solvent increases biocompatibility and the absence of N-protection is expected to maintain biological activity.