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High-resolution crystal structure of human protease-activated receptor 1

  • Author(s): Coughlin, Shaun
  • Zhang, C
  • Srinivasan, Y
  • Arlow, DH
  • Fung, JJ
  • Palmer, D
  • Zheng, Y
  • Green, HF
  • Pandey, A
  • Dror, RO
  • Shaw, DE
  • et al.

Published Web Location

http://europepmc.org/articles/PMC3531875?pdf=render
No data is associated with this publication.
Abstract

Protease-activated receptor 1 (PAR1) is the prototypical member of a family of G-protein-coupled receptors that mediate cellular responses to thrombin and related proteases. Thrombin irreversibly activates PAR1 by cleaving the amino-terminal exodomain of t

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