Widespread Dysregulation of Peptide Hormone Release in Mice Lacking Adaptor Protein AP-3
- Author(s): Edwards, Robert;
- Sirkis, DW;
- Edwards, RH;
- Asensio, CS
- et al.
Published Web Locationhttp://europepmc.org/articles/PMC3784564?pdf=render
The regulated secretion of peptide hormones, neural peptides and many growth factors depends on their sorting into large dense core vesicles (LDCVs) capable of regulated exocytosis. LDCVs form at the trans-Golgi network, but the mechanisms that sort protei