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Distinct immunological mechanisms of CTLA-4 and PD-1 blockade revealed by analyzing TCR usage in blood lymphocytes.

  • Author(s): Robert, Lidia;
  • Harview, Christina;
  • Emerson, Ryan;
  • Wang, Xiaoyan;
  • Mok, Stephen;
  • Homet, Blanca;
  • Comin-Anduix, Begonya;
  • Koya, Richard C;
  • Robins, Harlan;
  • Tumeh, Paul C;
  • Ribas, Antoni
  • et al.
Abstract

Targeting immune inhibitory receptors has brought excitement, innovation and hope to cancer patients. Our recent work revealed the immunological effects of blocking the CTLA4 and PD-1 immune checkpoints on T cell receptor usage among peripheral blood cells, and further uncovers how the expansion of the T cell repertoire matches the immunotoxicity profile of the therapy.

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