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Resting heart rate as a low tech predictor of coronary events in women: prospective cohort study.
- Author(s): Hsia, Judith;
- Larson, Joseph C;
- Ockene, Judith K;
- Sarto, Gloria E;
- Allison, Matthew A;
- Hendrix, Susan L;
- Robinson, Jennifer G;
- LaCroix, Andrea Z;
- Manson, JoAnn E;
- Women's Health Initiative Research Group
- et al.
Published Web Locationhttp://10.0.4.112/bmj.b219
No data is associated with this publication.
ObjectiveTo evaluate resting heart rate as an independent predictor of cardiovascular risk in women.
DesignProspective cohort study.
SettingThe Women's Health Initiative was undertaken at 40 research clinics in the United States.
Participants129 135 postmenopausal women.
Main outcome measureClinical cardiovascular events.
ResultsDuring a mean of 7.8 (SD 1.6) years of follow up, 2281 women were identified with myocardial infarction or coronary death and 1877 with stroke. We evaluated associations between resting heart rate and cardiovascular events in Cox regression models adjusted for multiple covariates. Higher resting heart rate was independently associated with coronary events (hazard ratio 1.26, 95% confidence interval 1.11 to 1.42 for highest [>76 beats per minute] v lowest quintile [ConclusionResting heart rate, a low tech and inexpensive measure of autonomic tone, independently predicts myocardial infarction or coronary death, but not stroke, in women.
Trial registrationClinicalTrials.gov NCT00000611.
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