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Open Access Publications from the University of California

The role of inflammation in age-related disease.

  • Author(s): Howcroft, T Kevin;
  • Campisi, Judith;
  • Louis, Germaine Buck;
  • Smith, Martyn T;
  • Wise, Bradley;
  • Wyss-Coray, Tony;
  • Augustine, Alison Deckhut;
  • McElhaney, Janet E;
  • Kohanski, Ron;
  • Sierra, Felipe
  • et al.

The National Institutes of Health (NIH) Geroscience Interest Group (GSIG) sponsored workshop, The Role of Inflammation inAge-Related Disease, was held September 6th-7th, 2012 in Bethesda, MD. It is now recognized that a mild pro-inflammatory state is correlated with the major degenerative diseases of the elderly. The focus of the workshop was to better understand the origins and consequences of this low level chronic inflammation in order to design appropriate interventional studies aimed at improving healthspan. Four sessions explored the intrinsic, environmental exposures and immune pathways by which chronic inflammation are generated, sustained, and lead to age-associated diseases. At the conclusion of the workshop recommendations to accelerate progress toward understanding the mechanistic bases of chronic disease were identified.

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