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Open Access Publications from the University of California

Atomic-accuracy models from 4.5-Å cryo-electron microscopy data with density-guided iterative local refinement

  • Author(s): Cheng, Yifan
  • Dimaio, F
  • Song, Y
  • Li, X
  • Brunner, MJ
  • Xu, C
  • Conticello, V
  • Egelman, E
  • Marlovits, TC
  • Baker, D
  • et al.

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We describe a general approach for refining protein structure models on the basis of cryo-electron microscopy maps with near-atomic resolution. The method integrates Monte Carlo sampling with local density-guided optimization, Rosetta all-atom refinement a

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