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A Mouse Model Uncovers LKB1 as an UVB-Induced DNA Damage Sensor Mediating CDKN1A (p21WAF1/CIP1) Degradation

  • Author(s): Bastian, Boris
  • Esteve-Puig, R
  • Gil, R
  • González-Sánchez, E
  • Bech-Serra, JJ
  • Grueso, J
  • Hernández-Losa, J
  • Moliné, T
  • Canals, F
  • Ferrer, B
  • Cortés, J
  • et al.

Published Web Location

http://europepmc.org/articles/PMC4199501?pdf=render
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Abstract

© 2014 Esteve-Puig et al.Exposure to ultraviolet (UV) radiation from sunlight accounts for 90% of the symptoms of premature skin aging and skin cancer. The tumor suppressor serine-threonine kinase LKB1 is mutated in Peutz-Jeghers syndrome and in a spectrum

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