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Open Access Publications from the University of California

Prognostic value of age adjusted segment involvement score as measured by coronary computed tomography: a potential marker of vascular age.

  • Author(s): Ayoub, Chadi
  • Kritharides, Leonard
  • Yam, Yeung
  • Chen, Li
  • Hossain, Alomgir
  • Achenbach, Stephan
  • Al-Mallah, Mouaz H
  • Andreini, Daniele
  • Berman, Daniel S
  • Budoff, Matthew J
  • Cademartiri, Filippo
  • Callister, Tracy Q
  • Chang, Hyuk-Jae
  • Chinnaiyan, Kavitha
  • Cury, Ricardo C
  • Delago, Augustin
  • Dunning, Allison
  • Feuchtner, Gudrun
  • Gomez, Millie
  • Gransar, Heidi
  • Hadamitzky, Martin
  • Hausleiter, Joerg
  • Hindoyan, Niree
  • Kaufmann, Philipp A
  • Kim, Yong-Jin
  • Leipsic, Jonathon
  • Maffei, Erica
  • Marques, Hugo
  • Pontone, Gianluca
  • Raff, Gilbert
  • Rubinshtein, Ronen
  • Shaw, Leslee J
  • Villines, Todd C
  • Min, James K
  • Chow, Benjamin JW
  • et al.

Extent of coronary atherosclerotic disease (CAD) burden on coronary computed tomography angiography (CCTA) as measured by segment involvement score (SIS) has a prognostic value. We sought to investigate the incremental prognostic value of 'age adjusted SIS' (aSIS), which may be a marker of premature atherosclerosis and vascular age. Consecutive patients were prospectively enrolled into the CONFIRM (Coronary CT Angiography EvaluatioN For Clinical Outcomes: An InteRnational Multicentre) multinational observational study. Patients were followed for the outcome of all-cause death. aSIS was calculated on CCTA for each patient, and its incremental prognostic value was evaluated. A total of 22,211 patients [mean age 58.5 ± 12.7 years, 55.8% male) with a median follow-up of 27.3 months (IQR 17.8, 35.4)] were identified. After adjustment for clinical factors and presence of obstructive CAD, higher aSIS was associated with increased death on multivariable analysis, with hazard ratio (HR) 2.40 (1.83-3.16, p < 0.001), C-statistic 0.723 (0.700-0.756), net reclassification improvement (NRI) 0.36 (0.26-0.47, p < 0.001), and relative integrated discrimination improvement (IDI) 0.33 (p = 0.009). aSIS had HR 3.48 (2.33-5.18, p < 0.001) for mortality in those without obstructive CAD, compared to HR 1.79 (1.25-2.58, p = 0.02) in those with obstructive CAD. In conclusion, aSIS has an incremental prognostic value to traditional risk factors and obstructive CAD, and may enhance CCTA risk stratification.

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