Pathogenesis and pathophysiology of endometriosis
- Author(s): Burney, RO
- Giudice, LC
- et al.
Published Web Locationhttps://doi.org/10.1016/j.fertnstert.2012.06.029
Originally described over three hundred years ago, endometriosis is classically defined by the presence of endometrial glands and stroma in extrauterine locations. Endometriosis is an inflammatory, estrogen-dependent condition associated with pelvic pain and infertility. This work reviews the disease process from theories regarding origin to the molecular basis for disease sequelae. A thorough understanding of the histopathogenesis and pathophysiology of endometriosis is essential to the development of novel diagnostic and treatment approaches for this debilitating condition. © 2012 by American Society for Reproductive Medicine.