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Genome Sequence of Human Cytomegalovirus Ig-KG-H2, a Variant of Strain KG Propagated in the Presence of Neutralizing Antibodies.

  • Author(s): Al Qaffas, Ahmed;
  • Camiolo, Salvatore;
  • Nichols, Jenna;
  • Davison, Andrew J;
  • Ourahmane, Amine;
  • Cui, Xiaohong;
  • Schleiss, Mark R;
  • Hertel, Laura;
  • Dittmer, Dirk P;
  • McVoy, Michael A
  • et al.
Abstract

Human cytomegalovirus shed in infant urine was isolated and serially passaged in fibroblasts in the presence or absence of neutralizing antibodies. Comparison of the genome sequences of representative viruses Ig-KG-H2 (passed with antibody) and ϕ-KG-B5 (passed without antibody) revealed the presence of several mutations in each virus.

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