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Immune cell expression of GABAAreceptors and the effects of diazepam on influenza infection

  • Author(s): Sanders, RD
  • Grover, V
  • Goulding, J
  • Godlee, A
  • Gurney, S
  • Snelgrove, R
  • Ma, D
  • Singh, S
  • Maze, M
  • Hussell, T
  • et al.

Published Web Location

http://www.sciencedirect.com/science/article/pii/S0165572815000776?via=ihub
No data is associated with this publication.
Abstract

© 2015. Benzodiazepines increase vulnerability to infection through α1 subunit dependent ϒ-amino-butyric-type-A (GABAA) signalling. Immune cell expression of GABAAreceptors and the effect of diazepam on influenza infection was investigated. In patients with pneumonia, α1 GABAAsubunits were expressed on alveolar macrophages and blood monocytes. In mice, influenza induced dynamic changes in immune cell GABAAsubunit expression: α1 subunits decreased on alveolar macrophage, but increased on monocytes, CD4+ and CD8+ T cells. Following influenza viral infection, diazepam delayed weight loss on day 3 but later increased weight loss. Viral load was unaffected but increased bacterial superinfection was noted on day 10.

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