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Antagonistic actions of prostaglandins E2and F2alpha on the isolated lungs of the frog, Rana esculenta L.

  • Author(s): Piomelli, D
  • Pinto, A
  • Sannino, C
  • Tota, B
  • et al.
Abstract

1. Isolated lungs of the frog, Rana esculenta L., when incubated in amphibian Ringer solution for 30 min, produced a prostaglandin E2-like substance (27.1 + 3.8 ng/g w.w.), as determined by bioassay on the isolated rat stomach strip. 2. The release of PGE2-like substance from skin, heart and bowel is also reported. 3. The activity of synthetic prostaglandins E2(PGE2and F2alpha (PGF2alpha) on the muscular contractility of frog isolated lungs was investigated: PGE2and PGF2alpha relaxed and contracted respectively in a dose-dependent manner this preparation, a result similar to that obtained in mammals. © 1987.

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