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Open Access Publications from the University of California

CADM1 Function in Regards to Insulin Secretion in the Beta Cell /

  • Author(s): Nourollahi, Shokufeh
  • et al.

CADM1 (Cellular ADhesion Molecule 1) is a synaptic adhesion molecule found in a multitude of tissue types. CADM1 is a very versatile protein but its main function is facilitating communication between nerve cells. Recently it has been discovered that synaptic adhesion molecules such as CADM1 are involved in insulin release and regulation in the beta cells of the pancreas. For this project, we determined which CADM isoform has the highest level of expression in the beta cell and what effect CADM1 overexpression or knockdown would have in regards to insulin secretion. Preliminary results show CADM1 has the highest level of expression in rat islets, and the overexpression and knockdown of CADM1 in rat beta cell lines in basal glucose conditions leads to an increase in insulin secretion

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