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Insight into hepatocellular carcinoma biology with gadoxetate disodium-enhanced MRI.

  • Author(s): Kagen, Alexander
  • Fowler, Kathryn
  • Sirlin, Claude B
  • et al.

Published Web Location

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6114011/
No data is associated with this publication.
Abstract

The current algorithm for the imaging diagnosis of hepatocellular carcinoma accurately detects large, progressed tumors displaying the classical imaging features of arterial hyperenhancement with 'washout' and/or 'capsule' appearance. Liver MRI with the relatively newer hepatobiliary agent, gadoxetate disodium, provides information on hepatocellular function in addition to vascularity, facilitates detection of small progressed tumors, as well as early/vaguely nodular tumors, and shows promise for characterizing hepatocellular carcinoma biology. Prediction of tumor grade, presence of biliary and stem cell markers, microvascular invasion, future hypervascularization and post-treatment recurrence have all been studied with gadoxetate disodium-enhanced MRI with encouraging results. Incorporation of gadoxetate disodium-enhanced MRI into standard diagnostic and management algorithms will likely unfold in the future.

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