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Open Access Publications from the University of California

A chaperone-assisted degradation pathway targets kinetochore proteins to ensure genome stability.

  • Author(s): Krogan, Nevan
  • Kriegenburg, F
  • Jakopec, V
  • Poulsen, EG
  • Nielsen, SV
  • Roguev, A
  • Gordon, C
  • Fleig, U
  • Hartmann-Petersen, R
  • et al.

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Cells are regularly exposed to stress conditions that may lead to protein misfolding. To cope with this challenge, molecular chaperones selectively target structurally perturbed proteins for degradation via the ubiquitin-proteasome pathway. In mammals the

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