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A chaperone-assisted degradation pathway targets kinetochore proteins to ensure genome stability.

  • Author(s): Krogan, Nevan
  • Kriegenburg, F
  • Jakopec, V
  • Poulsen, EG
  • Nielsen, SV
  • Roguev, A
  • Gordon, C
  • Fleig, U
  • Hartmann-Petersen, R
  • et al.

Published Web Location

http://europepmc.org/articles/PMC3907333?pdf=render
No data is associated with this publication.
Abstract

Cells are regularly exposed to stress conditions that may lead to protein misfolding. To cope with this challenge, molecular chaperones selectively target structurally perturbed proteins for degradation via the ubiquitin-proteasome pathway. In mammals the

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