Skip to main content
Download PDF
- Main
Clinical, genomic, and metagenomic characterization of oral tongue squamous cell carcinoma in patients who do not smoke
- Li, Ryan;
- Faden, Daniel L;
- Fakhry, Carole;
- Langelier, Chaz;
- Jiao, Yuchen;
- Wang, Yuxuan;
- Wilkerson, Matthew D;
- Pedamallu, Chandra Sekhar;
- Old, Matthew;
- Lang, James;
- Loyo, Myriam;
- Ahn, Sun Mi;
- Tan, Marietta;
- Gooi, Zhen;
- Chan, Jason;
- Richmon, Jeremy;
- Wood, Laura D;
- Hruban, Ralph H;
- Bishop, Justin;
- Westra, William H;
- Chung, Christine H;
- Califano, Joseph;
- Gourin, Christine G;
- Bettegowda, Chetan;
- Meyerson, Matthew;
- Papadopoulos, Nickolas;
- Kinzler, Kenneth W;
- Vogelstein, Bert;
- DeRisi, Joseph L;
- Koch, Wayne M;
- Agrawal, Nishant
- et al.
Published Web Location
https://doi.org/10.1002/hed.23807Abstract
Background
Evidence suggests the incidence of oral tongue squamous cell carcinoma is increasing in young patients, many who have no history of tobacco use.Methods
We clinically reviewed 89 patients with oral tongue cancer. Exomic sequencing of tumor DNA from 6 nonsmokers was performed and compared to previously sequenced cases. RNA from 20 tumors was evaluated by massively parallel sequencing to search for potentially oncogenic viruses.Results
Non-smokers (53 of 89) were younger than smokers (36 of 89; mean, 50.4 vs 61.9 years; p < .001), and seemed more likely to be women (58.5% vs 38.9%; p = .069). Nonsmokers had fewer TP53 mutations (p = .02) than smokers. No tumor-associated viruses were detected.Conclusion
The young age of nonsmoking patients with oral tongue cancer and fewer TP53 mutations suggest a viral role in this disease. Our efforts to identify such a virus were unsuccessful. Further studies are warranted to elucidate the drivers of carcinogenesis in these patients.Many UC-authored scholarly publications are freely available on this site because of the UC's open access policies. Let us know how this access is important for you.
Main Content
For improved accessibility of PDF content, download the file to your device.
Enter the password to open this PDF file:
File name:
-
File size:
-
Title:
-
Author:
-
Subject:
-
Keywords:
-
Creation Date:
-
Modification Date:
-
Creator:
-
PDF Producer:
-
PDF Version:
-
Page Count:
-
Page Size:
-
Fast Web View:
-
Preparing document for printing…
0%