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Enzyme-Responsive Delivery of Multiple Proteins with Spatiotemporal Control

  • Author(s): Zhu, S
  • Nih, L
  • Carmichael, ST
  • Lu, Y
  • Segura, T
  • et al.
Abstract

© 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. Orchestrated biological materials such as enzymes and growth factors regulate the growth of tissues and organs. A chirality-controlled, single-protein technology is devised to tailor the spatiotemporally defined delivery of therapeutic proteins in response to natural enzymes present at wound sites. Sustained delivery of one protein and sequential delivery of two proteins are demonstrated for stroke and skin wound healing.

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