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Open Access Publications from the University of California

Naive CD4 T-cell activation identifies MS patients having rapid transition to progressive MS

  • Author(s): Baranzini, Sergio
  • Zastepa, E
  • Fitz-Gerald, L
  • Hallett, M
  • Antel, J
  • Bar-Or, A
  • Lapierre, Y
  • Haegert, DG
  • et al.

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Objective: Our objective was to determine whether altered naive CD4 T-cell biology contributes to development of disease progression in secondary progressive multiple sclerosis (SPMS). Methods: We compared the naive CD4 T-cell gene expression profiles of 1

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