Skip to main content
eScholarship
Open Access Publications from the University of California

UCLA

UCLA Previously Published Works bannerUCLA

GWAS analysis of handgrip and lower body strength in older adults in the CHARGE consortium.

  • Author(s): Matteini, Amy M
  • Tanaka, Toshiko
  • Karasik, David
  • Atzmon, Gil
  • Chou, Wen-Chi
  • Eicher, John D
  • Johnson, Andrew D
  • Arnold, Alice M
  • Callisaya, Michele L
  • Davies, Gail
  • Evans, Daniel S
  • Holtfreter, Birte
  • Lohman, Kurt
  • Lunetta, Kathryn L
  • Mangino, Massimo
  • Smith, Albert V
  • Smith, Jennifer A
  • Teumer, Alexander
  • Yu, Lei
  • Arking, Dan E
  • Buchman, Aron S
  • Chibinik, Lori B
  • De Jager, Philip L
  • Evans, Denis A
  • Faul, Jessica D
  • Garcia, Melissa E
  • Gillham-Nasenya, Irina
  • Gudnason, Vilmundur
  • Hofman, Albert
  • Hsu, Yi-Hsiang
  • Ittermann, Till
  • Lahousse, Lies
  • Liewald, David C
  • Liu, Yongmei
  • Lopez, Lorna
  • Rivadeneira, Fernando
  • Rotter, Jerome I
  • Siggeirsdottir, Kristin
  • Starr, John M
  • Thomson, Russell
  • Tranah, Gregory J
  • Uitterlinden, André G
  • Völker, Uwe
  • Völzke, Henry
  • Weir, David R
  • Yaffe, Kristine
  • Zhao, Wei
  • Zhuang, Wei Vivian
  • Zmuda, Joseph M
  • Bennett, David A
  • Cummings, Steven R
  • Deary, Ian J
  • Ferrucci, Luigi
  • Harris, Tamara B
  • Kardia, Sharon LR
  • Kocher, Thomas
  • Kritchevsky, Stephen B
  • Psaty, Bruce M
  • Seshadri, Sudha
  • Spector, Timothy D
  • Srikanth, Velandai K
  • Windham, B Gwen
  • Zillikens, M Carola
  • Newman, Anne B
  • Walston, Jeremy D
  • Kiel, Douglas P
  • Murabito, Joanne M
  • et al.

Published Web Location

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5013019/
No data is associated with this publication.
Abstract

Decline in muscle strength with aging is an important predictor of health trajectory in the elderly. Several factors, including genetics, are proposed contributors to variability in muscle strength. To identify genetic contributors to muscle strength, a meta-analysis of genomewide association studies of handgrip was conducted. Grip strength was measured using a handheld dynamometer in 27 581 individuals of European descent over 65 years of age from 14 cohort studies. Genomewide association analysis was conducted on ~2.7 million imputed and genotyped variants (SNPs). Replication of the most significant findings was conducted using data from 6393 individuals from three cohorts. GWAS of lower body strength was also characterized in a subset of cohorts. Two genomewide significant (P-value< 5 × 10(-8) ) and 39 suggestive (P-value< 5 × 10(-5) ) associations were observed from meta-analysis of the discovery cohorts. After meta-analysis with replication cohorts, genomewide significant association was observed for rs752045 on chromosome 8 (β = 0.47, SE = 0.08, P-value = 5.20 × 10(-10) ). This SNP is mapped to an intergenic region and is located within an accessible chromatin region (DNase hypersensitivity site) in skeletal muscle myotubes differentiated from the human skeletal muscle myoblasts cell line. This locus alters a binding motif of the CCAAT/enhancer-binding protein-β (CEBPB) that is implicated in muscle repair mechanisms. GWAS of lower body strength did not yield significant results. A common genetic variant in a chromosomal region that regulates myotube differentiation and muscle repair may contribute to variability in grip strength in the elderly. Further studies are needed to uncover the mechanisms that link this genetic variant with muscle strength.

Many UC-authored scholarly publications are freely available on this site because of the UC's open access policies. Let us know how this access is important for you.

Item not freely available? Link broken?
Report a problem accessing this item