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Right- and left-loop short shRNAs have distinct and unusual mechanisms of gene silencing.
Published Web Location
http://europepmc.org/articles/PMC3467060?pdf=renderNo data is associated with this publication.
Abstract
Small hairpin RNAs (shRNAs) having duplex lengths of 25-29 bp are normally processed by Dicer into short interfering RNAs (siRNAs) before incorporation into the RNA-induced silencing complex (RISC). However, shRNAs of ≤ 19 bp [short shRNAs (sshRNAs)] are t
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