Skip to main content
Open Access Publications from the University of California


UC San Francisco Previously Published Works bannerUCSF

How do you mend inactive tumor suppressor mutants? You glue them!

  • Author(s): Hata, Akiko
  • Lagna, Giorgio
  • et al.

SMAD4 mutations that disrupt its interaction with SMAD3 and attenuate tumor suppression by TGF-β are major oncogenic drivers. Tang et al. (2020) report the discovery of small molecules that restore the SMAD4:SMAD3 complex and its cytostatic activity, exemplifying the therapeutic potential of fixing tumor suppressor mutants using molecular glues.

Many UC-authored scholarly publications are freely available on this site because of the UC's open access policies. Let us know how this access is important for you.

Main Content
Current View