How do you mend inactive tumor suppressor mutants? You glue them!
- Author(s): Hata, Akiko
- Lagna, Giorgio
- et al.
Published Web Locationhttps://doi.org/10.1016/j.chembiol.2021.04.023
SMAD4 mutations that disrupt its interaction with SMAD3 and attenuate tumor suppression by TGF-β are major oncogenic drivers. Tang et al. (2020) report the discovery of small molecules that restore the SMAD4:SMAD3 complex and its cytostatic activity, exemplifying the therapeutic potential of fixing tumor suppressor mutants using molecular glues.