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How do you mend inactive tumor suppressor mutants? You glue them!

  • Author(s): Hata, Akiko
  • Lagna, Giorgio
  • et al.
Abstract

SMAD4 mutations that disrupt its interaction with SMAD3 and attenuate tumor suppression by TGF-β are major oncogenic drivers. Tang et al. (2020) report the discovery of small molecules that restore the SMAD4:SMAD3 complex and its cytostatic activity, exemplifying the therapeutic potential of fixing tumor suppressor mutants using molecular glues.

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