Skip to main content
Open Access Publications from the University of California

The NEIGHBOR consortium primary open-angle glaucoma genome-wide association study: rationale, study design, and clinical variables.

  • Author(s): Wiggs, Janey L
  • Hauser, Michael A
  • Abdrabou, Wael
  • Allingham, Robert Rand
  • Budenz, Donald L
  • Delbono, Elizabeth
  • Friedman, David S
  • Kang, Jae H
  • Gaasterland, Douglas
  • Gaasterland, Terry
  • Lee, Richard K
  • Lichter, Paul R
  • Loomis, Stephanie
  • Liu, Yutao
  • McCarty, Cathy
  • Medeiros, Felipe A
  • Moroi, Sayoko E
  • Olson, Lana M
  • Realini, Anthony
  • Richards, Julia E
  • Rozsa, Frank W
  • Schuman, Joel S
  • Singh, Kuldev
  • Stein, Joshua D
  • Vollrath, Douglas
  • Weinreb, Robert N
  • Wollstein, Gadi
  • Yaspan, Brian L
  • Yoneyama, Sachiko
  • Zack, Don
  • Zhang, Kang
  • Pericak-Vance, Margaret
  • Pasquale, Louis R
  • Haines, Jonathan L
  • et al.

Published Web Location
No data is associated with this publication.

Primary open-angle glaucoma (POAG) is a common disease with complex inheritance. The identification of genes predisposing to POAG is an important step toward the development of novel gene-based methods of diagnosis and treatment. Genome-wide association studies (GWAS) have successfully identified genes contributing to complex traits such as POAG however, such studies frequently require very large sample sizes, and thus, collaborations and consortia have been of critical importance for the GWAS approach. In this report we describe the formation of the NEIGHBOR consortium, the harmonized case control definitions used for a POAG GWAS, the clinical features of the cases and controls, and the rationale for the GWAS study design.

Many UC-authored scholarly publications are freely available on this site because of the UC's open access policies. Let us know how this access is important for you.

Item not freely available? Link broken?
Report a problem accessing this item