Skip to main content
eScholarship
Open Access Publications from the University of California

UCLA

UCLA Previously Published Works bannerUCLA

Fully integrated CMOS nano-particle assembly circuit for biological detections

Abstract

Recently, along with the booming of research and production of CMOS Integrated Bio-sensing System, selective assembly of organic nano-particles on the on-chip electrodes, which serves for specific bio-sensing and detection purposes, is in high demand in areas like biological analysis and detection, DNA probing and surveying systems and etc. In this paper, a fully integrated bio-circuit targeting at electrical selective assembly of charged nano-particles is proposed and designed in SMIC 0.18 μm CMOS mixed signal process. The proposed circuit integrates the 16 pixels of 19 μm × 19 μm electrode array, counter electrode, potentiostat circuit, digital decoding circuit, as well as control logics on a single chip, and provides a rail-to-rail range of assembling voltage, a potential resolution of 8 bit, and a maximal assembling current up to 459 μA, biased at a current of 1 μA. Meanwhile, a novel electrode-reuse scheme is also proposed to further simplify the architecture and save chip area as well, without degrading the functionalities. Experimental results from on-chip selective assembly of 50 nm polystyrene nano-particles are included and discussed to verify the feasibility of the proposed circuits.

Many UC-authored scholarly publications are freely available on this site because of the UC's open access policies. Let us know how this access is important for you.

Main Content
For improved accessibility of PDF content, download the file to your device.
Current View