Schnittman, Samuel R; Kitch, Douglas W; Swartz, Talia H; Burdo, Tricia H; Fitch, Kathleen V; McCallum, Sara; Flynn, Jacqueline M; Fulda, Evelynne S; Diggs, Marissa R; Stapleton, Jack T; Casado, José L; Taron, Jana; Currier, Judith S; Zanni, Markella V; Malvestutto, Carlos; Fichtenbaum, Carl J; Aberg, Judith A; Ribaudo, Heather J; Lu, Michael T; Douglas, Pamela S; Grinspoon, Steven K

doi:10.1093/ofid/ofad106

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Coronary Artery Plaque Composition and Severity Relate to the Inflammasome in People With Treated Human Immunodeficiency Virus

Published Web Location

https://doi.org/10.1093/ofid/ofad106

Abstract

Background

Inflammasome activation is increased in people with human immunodeficiency virus (PWH), but its relationship with coronary plaque is poorly understood in this setting.

Methods

In a large human immunodeficiency virus cardiovascular prevention cohort, relationships between caspase-1, interleukin (IL)-1β, and IL-18 and coronary plaque indices were assessed by multivariate logistic regression.

Results

Higher IL-18 and IL-1β were associated with Leaman score, an integrative measure of plaque burden and composition.

Conclusions

As Leaman score >5 is associated with cardiovascular events in the general population, future work is needed to determine how the inflammasome relates to events and whether strategies to reduce its activation affect events or plaque progression among PWH.

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