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The Way of Tau: Secretion and Synaptic Dysfunction

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https://doi.org/10.1016/j.molmed.2018.05.006
Abstract

Tau, a microtubule-associated protein, is linked to many neurodegenerative diseases, including Alzheimer's disease (AD). A recent study uncovered a new pathway for its secretion, leading to its transcellular uptake, while another study found that tau secreted from human induced pluripotent stem cells (iPSCs) modeling trisomy 21-related AD caused synaptic impairment in rats. These findings could inform tau-directed therapies.

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