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Of mice, men and immunity: a case for evolutionary systems biology
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https://doi.org/10.1038/s41590-018-0084-4Abstract
Animal models have been tremendously useful to translational research, but there is a need to maximize their predictive value to human disease. This Comment proposes novel strategies that consider evolutionary history and the presence, absence or modification of molecular networks in one species that are being studied in the other.
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