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RRx-001 in Refractory Small-Cell Lung Carcinoma: A Case Report of a Partial Response after a Third Reintroduction of Platinum Doublets.

  • Author(s): Carter, Corey A
  • Oronsky, Bryan T
  • Caroen, Scott Z
  • Scicinski, Jan J
  • Degesys, Aiste
  • Kim, Michelle M
  • Oronsky, Arnold L
  • Lybeck, Harry
  • Cabrales, Pedro
  • Oronsky, Neil
  • Reid, Tony
  • Roswarski, Joseph
  • Brzezniak, Christina
  • et al.

Published Web Location

https://doi.org/10.1159/000444631
Abstract

RRx-001 is a pan-active, systemically nontoxic epigenetic inhibitor under investigation in advanced non-small cell lung cancer, small-cell lung cancer and high-grade neuroendocrine tumors in a Phase II clinical trial entitled TRIPLE THREAT (NCT02489903), which reexposes patients to previously effective but refractory platinum doublets after treatment with RRx-001. The purpose of this case study is first to report a partial response to carboplatin and etoposide in a patient with small-cell lung cancer pretreated with RRx-001, indicating episensitization or resensitization by epigenetic mechanisms, and second to discuss the literature related to small-cell lung cancer and episensitization.

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