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Chiral aminophosphines derived from hydroxyproline and their application in allene–imine [4 + 2] annulation
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https://doi.org/10.1038/s41429-019-0181-0Abstract
A robust synthetic route from L-hydroxyproline (L-Hyp) to phosphines has established an expandable library of six chiral aminophosphines, which were then applied to the phosphine-catalyzed [4 + 2] allene-imine annulation. The enantioinduction in the annulations-induced by a purely steric effect-were moderate (up to 57% ee). A switch of the reaction site from the γ- to the β'-carbon atom of the allenoate was observed during the annulations performed using sterically demanding chiral phosphines.
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