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Stealing VEGF from thy neighbor.
- Author(s): Domigan, Courtney K
- Iruela-Arispe, M Luisa
- et al.
Published Web Locationhttps://www.sciencedirect.com/science/article/pii/S0092867414012951
The distribution and patterning of blood vessels is controlled by vascular endothelial growth factor (VEGF), which is precisely regulated throughout its life cycle. Okabe et al. show that VEGF is titrated away from the endothelium by adjacent neurons via endocytosis, regulating density and trajectory of blood vessels.