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Phase I clinical trial results of verteporfin enhanced feeder vessel therapy in subfoveal choroidal neovascularisation in age related macular degeneration.

  • Author(s): Kozak, I
  • Cheng, L
  • Cochran, D E
  • Freeman, W R
  • et al.
Abstract

Aims: To investigate the safety and effectiveness of extrafoveal photodynamic therapy (PDT) occlusion of feeder vessels (FVs) in patients with subfoveal choroidal neovascularisation (CNV) as a result of age related macular degeneration. Methods: FVs were identified using dynamic fluorescein and indocyanine green angiography with scanning laser ophthalmoscope. The standard doses of verteporfin and laser wavelength were used. The light dose was escalated by increasing the duration of the light dose so the light regimen was 50 J/cm(2) for patients 1 and 2; 100 J/cm(2) for patients 3, 4, 5; 125 J/cm(2) for patients 6 and 7; and 150 J/cm(2) for patients 8 and 9. Patients were examined at weeks 1, 4, and 12. Results: The mean improvement on EDTRS chart 3 months after treatment was an increase of 2.1 lines (p=0.07). Closure of the FV was achieved angiographically in three eyes at various light doses, in three eyes the FV was hypoperfused, and in three eyes the vessels were were neither closed nor hypoperfused. At the last follow up all FVs were reperfused. There was no evidence of retinal damage. Conclusion: Verteporfin enhanced FV therapy does not cause subfoveal retinal damage and may have potential to improve central vision in subfoveal CNV caused by exudative macular degeneration. It is not recommended as a monotherapy for CNV.

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