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Lipoprotein lipase does not increase significantly in the postprandial plasma.

  • Author(s): Ishiyama, Nobuyoshi
  • Sakamaki, Kouji
  • Shimomura, Younosuke
  • Kotani, Kazuhiko
  • Tsuzaki, Kokoro
  • Sakane, Naoki
  • Miyashita, Kazuya
  • Fukamachi, Isao
  • Kobayashi, Junji
  • Stanhope, Kimber L
  • Havel, Peter J
  • Kamachi, Keiko
  • Tanaka, Akira
  • Tokita, Yoshiharu
  • Machida, Tetsuo
  • Murakami, Masami
  • Nakajima, Katsuyuki
  • et al.
Abstract

Previous reports have shown that lipoprotein lipase (LPL) activity significantly increases in the postprandial plasma associated with the increase of TG-rich lipoproteins. Therefore, we have reexamined those relationships using newly developed LPL assay with the different kinds of food intake.Standard meal (n=81), 50g of fat (n=54), 75g of glucose (n=25) and cookie (25g fat and 75g carbohydrate fat) (n=28) were administered in generally healthy volunteers. Plasma LPL, HTGL and TC, TG, LDL-C, HDL-C, RLP-C and RLP-TG were determined at subsequent withdrawal after the food intake.Plasma TG, RLP-C and RLP-TG were significantly increased at 8PM (2h after dinner of standard meal) compared with 8AM before breakfast within the same day. Also those parameters were significantly increased in 2-6h after fat load. However, the concentrations and activities of LPL and HTGL did not significantly increase in association with an increase in the TG and remnant lipoproteins. Also LPL concentration did not significantly increase after glucose and "cookie test" within 4h.No significant increase of LPL activity was found at CM and VLDL overload after different kinds of food intake when reexamined by newly developed assay for LPL activity and concentration.

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