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Photo-redox activated drug delivery systems operating under two photon excitation in the near-IR.

  • Author(s): Guardado-Alvarez, Tania M
  • Devi, Lekshmi Sudha
  • Vabre, Jean-Marie
  • Pecorelli, Travis A
  • Schwartz, Benjamin J
  • Durand, Jean-Olivier
  • Mongin, Olivier
  • Blanchard-Desce, Mireille
  • Zink, Jeffrey I
  • et al.
Abstract

We report the design and synthesis of a nano-container consisting of mesoporous silica nanoparticles with the pore openings covered by "snap-top" caps that are opened by near-IR light. A photo transducer molecule that is a reducing agent in an excited electronic state is covalently attached to the system. Near IR two-photon excitation causes inter-molecular electron transfer that reduces a disulfide bond holding the cap in place, thus allowing the cargo molecules to escape. We describe the operation of the "snap-top" release mechanism by both one- and two-photon activation. This system presents a proof of concept of a near-IR photoredox-induced nanoparticle delivery system that may lead to a new type of photodynamic drug release therapy.

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