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Dnmt3a regulates emotional behavior and spine plasticity in the nucleus accumbens
- LaPlant, Quincey;
- Vialou, Vincent;
- Covington, Herbert E;
- Dumitriu, Dani;
- Feng, Jian;
- Warren, Brandon L;
- Maze, Ian;
- Dietz, David M;
- Watts, Emily L;
- Iñiguez, Sergio D;
- Koo, Ja Wook;
- Mouzon, Ezekiell;
- Renthal, William;
- Hollis, Fiona;
- Wang, Hui;
- Noonan, Michele A;
- Ren, Yanhua;
- Eisch, Amelia J;
- Bolaños, Carlos A;
- Kabbaj, Mohamed;
- Xiao, Guanghua;
- Neve, Rachael L;
- Hurd, Yasmin L;
- Oosting, Ronald S;
- Fan, Gouping;
- Morrison, John H;
- Nestler, Eric J
Published Web Location
https://doi.org/10.1038/nn.2619Abstract
The authors find that the expression of the DNA methyltransferase Dnmt3a in mice is regulated by chronic cocaine and chronic social defeat stress in the nucleus accumbens. Manipulations that block DNA methylation potentiate cocaine reward and cause an antidepressant-like effect.
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