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The Difference δ-Cells Make in Glucose Control.

  • Author(s): Huising, Mark O
  • van der Meulen, Talitha
  • Huang, Jessica L
  • Pourhosseinzadeh, Mohammad S
  • Noguchi, Glyn M
  • et al.

The role of beta and α-cells to glucose control are established, but the physiological role of δ-cells is poorly understood. Delta-cells are ideally positioned within pancreatic islets to modulate insulin and glucagon secretion at their source. We review the evidence for a negative feedback loop between delta and β-cells that determines the blood glucose set point and suggest that local δ-cell-mediated feedback stabilizes glycemic control.

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