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Recurrent noncoding regulatory mutations in pancreatic ductal adenocarcinoma
- Feigin, Michael E;
- Garvin, Tyler;
- Bailey, Peter;
- Waddell, Nicola;
- Chang, David K;
- Kelley, David R;
- Shuai, Shimin;
- Gallinger, Steven;
- McPherson, John D;
- Grimmond, Sean M;
- Khurana, Ekta;
- Stein, Lincoln D;
- Biankin, Andrew V;
- Schatz, Michael C;
- Tuveson, David A
Published Web Location
https://doi.org/10.1038/ng.3861Abstract
Michael Schatz, David Tuveson and colleagues analyze somatic noncoding alterations in 308 pancreatic ductal adenocarcinomas. They find recurrent noncoding regulatory mutations that correlate with differential expression of proximal genes and find that the strongest regulatory elements are more frequently mutated, suggesting a selective advantage for mutations in these regions.
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