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A regulatory pathway involving Notch1/β-catenin/Isl1 determines cardiac progenitor cell fate.

Published Web Location

https://doi.org/10.1038/ncb1906
Abstract

Notch1 inhibits cardiac progenitor cell expansion by preventing the accumulation of phosphorylated β-catenin, which normally promotes their proliferation. In a feedback loop, Notch1 positively regulates the expression of cardiac transcription factors to induce progenitor cell differentiation, whereas β-catenin has the reverse effect.

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