Fishing for biodiversity: Novel methanopterin-linked C1 transfer genes deduced from the Sargasso Sea metagenome
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Fishing for biodiversity: Novel methanopterin-linked C1 transfer genes deduced from the Sargasso Sea metagenome

  • Author(s): Kalyuzhnaya, Marina G.
  • Nercessian, Olivier
  • Lapidus, Alla
  • Chistoserdova, Ludmila
  • et al.
Abstract

The recently generated database of microbial genes from an oligotrophic environment populated by a calculated 1,800 of major phylotypes (the Sargasso Sea metagenome) presents a great source for expanding local databases of genes indicative of a specific function. In this paper we analyze the Sargasso Sea metagenome in terms of the presence of methanopterin-linked C1 transfer genes that are signature for methylotrophy. We conclude that more than 10 phylotypes possessing genes of interest are present in this environment, and a few of these are relatively abundant species. The sequences representative of the major phylotypes do not appear to belong to any known microbial group capable of methanopterin-linked C1 transfer. Instead, they separate from all known sequences on phylogenetic trees, pointing towards their affiliation with a novel microbial phylum. These data imply a broader distribution of methanopterin-linked functions in the microbial world than previously known.

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