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The Xist lncRNA interacts directly with SHARP to silence transcription through HDAC3
- McHugh, Colleen A;
- Chen, Chun-Kan;
- Chow, Amy;
- Surka, Christine F;
- Tran, Christina;
- McDonel, Patrick;
- Pandya-Jones, Amy;
- Blanco, Mario;
- Burghard, Christina;
- Moradian, Annie;
- Sweredoski, Michael J;
- Shishkin, Alexander A;
- Su, Julia;
- Lander, Eric S;
- Hess, Sonja;
- Plath, Kathrin;
- Guttman, Mitchell
Published Web Location
https://doi.org/10.1038/nature14443Abstract
The mechanisms by which Xist, a long non-coding RNA, silences one X chromosome in female mammals are unknown; here a mass spectrometry-based approach is developed to identify several proteins that interact directly with Xist, including the transcriptional repressor SHARP that is required for transcriptional silencing through the histone deacetylase HDAC3.
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