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Discovery of GBT440, an Orally Bioavailable R-State Stabilizer of Sickle Cell Hemoglobin

  • Author(s): Metcalf, Brian;
  • Chuang, Chihyuan;
  • Dufu, Kobina;
  • Patel, Mira P;
  • Silva-Garcia, Abel;
  • Johnson, Carl;
  • Lu, Qing;
  • Partridge, James R;
  • Patskovska, Larysa;
  • Patskovsky, Yury;
  • Almo, Steven C;
  • Jacobson, Matthew P;
  • Hua, Lan;
  • Xu, Qing;
  • Gwaltney, Stephen L;
  • Yee, Calvin;
  • Harris, Jason;
  • Morgan, Bradley P;
  • James, Joyce;
  • Xu, Donghong;
  • Hutchaleelaha, Athiwat;
  • Paulvannan, Kumar;
  • Oksenberg, Donna;
  • Li, Zhe
  • et al.
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