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Cross-reactive antibody response to mRNA SARS-CoV-2 vaccine after recent COVID-19-specific monoclonal antibody therapy
- Schultz-Cherry, Stacey;
- McGargill, Maureen A;
- Thomas, Paul G;
- Estepp, Jeremie H;
- Gaur, Aditya H;
- Allen, E Kaitlynn;
- Allison, Kim J;
- Tang, Li;
- Webby, Richard J;
- Cherry, Sean D;
- Lin, Chun-Yang;
- Fabrizio, Thomas;
- Tuomanen, Elaine I;
- Wolf, Joshua;
- Roubidoux, Ericka Kirkpatrick;
- Freiden, Pamela;
- Mori, Tomi;
- Hijano, Diego R;
- Hakim, Hana;
- Brice, David C;
- Castellaw, Ashley;
- Krammer, Florian;
- Wittman, David E;
- Hodges, Jason;
- Dallas, Ronald H;
- Cortez, Valerie;
- Vazquez-Pagan, Ana;
- Bajracharya, Resha;
- Clark, Brandi L;
- Van de Velde, Lee-Ann;
- Awad, Walid;
- Wilson, Taylor L;
- Kirk, Allison M;
- Hayden, Randall T;
- Hoffman, James;
- Russell-Bell, Jamie;
- Sparks, James
- et al.
Published Web Location
https://doi.org/10.1093/ofid/ofab420Abstract
The efficacy of coronavirus disease 2019 (COVID-19) vaccines administered after COVID-19-specific monoclonal antibody is unknown, and "antibody interference" might hinder immune responses leading to vaccine failure. In an institutional review board-approved prospective study, we found that an individual who received mRNA COVID-19 vaccination <40 days after COVID-19-specific monoclonal antibody therapy for symptomatic COVID-19 had similar postvaccine antibody responses to SARS-CoV-2 receptor binding domain (RBD) for 4 important SARS-CoV-2 variants (B.1, B.1.1.7, B.1.351, and P.1) as other participants who were also vaccinated following COVID-19. Vaccination against COVID-19 shortly after COVID-19-specific monoclonal antibody can boost and expand antibody protection, questioning the need to delay vaccination in this setting.
Trial registration
The St. Jude Tracking of Viral and Host Factors Associated with COVID-19 study; NCT04362995; https://clinicaltrials.gov/ct2/show/NCT04362995.Many UC-authored scholarly publications are freely available on this site because of the UC's open access policies. Let us know how this access is important for you.
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