Higher Human T Lymphotropic Virus (HTLV) provirus load is associated with HTLV-I versus HTLV-II, with HTLV-II subtype A versus B, and with male sex and a history of blood transfusion
- Author(s): Murphy, EL
- Lee, TH
- Chafets, D
- Nass, CC
- Wang, B
- Loughlin, K
- Smith, D
- et al.
Published Web Locationhttp://jid.oxfordjournals.org/content/190/3/504.long
Background. High human T lymphotropic virus (HTLV)-I provirus load (VL) has been associated with an increased risk of HTLV-associated myelopathy, but little is known about variation in HTLV-I or -II VLs by demographic characteristics and risk behaviors. Methods. We measured HTLV-I and HTLV-II VLs in a large cohort of 127 HTLV-I-seropositive and 328 HTLV-II-seropositive former blood donors, by use of real-time polymerase chain reaction using tax primers. Multivariable linear regression was used to control for confounding by relevant covariates. Results. The mean VLs were 3.28 log10copies/106peripheral blood mononuclear cells (PBMCs) (range, 0.5-5.3 log10copies/106PBMCs) for HTLV-I and 2.60 log10copies/106PBMCs (range, 0.05-5.95 log10copies/106PBMCs) for HTLV-II (P < .0001). HTLV-II VLs were higher in those subjects with subtype A infection (mean, 2.82 log10copies/106PBMCs) than in those with subtype B infection (mean, 2.29 log10copies/106PBMCs) (P = .005). Higher HTLV-I VL was associated with previous receipt of a blood transfusion (P = .04), and lower HTLV-II VL was associated with female sex (P = .007). These associations persisted in virus-specific multivariate linear regression models controlling for potential confounding variables. Conclusions. VL was significantly higher in HTLV-I than in HTLV-II infection and was higher in HTLV-II subtype A than in HTLV-II subtype B infection. Chronic HTLV VLs may be related to the infectious dose acquired at the time of infection, with higher VLs following acquisition by blood transfusion and lower VLs following sexual acquisition.
Many UC-authored scholarly publications are freely available on this site because of the UC Academic Senate's Open Access Policy. Let us know how this access is important for you.