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Higher Human T Lymphotropic Virus (HTLV) provirus load is associated with HTLV-I versus HTLV-II, with HTLV-II subtype A versus B, and with male sex and a history of blood transfusion

  • Author(s): Murphy, EL
  • Lee, TH
  • Chafets, D
  • Nass, CC
  • Wang, B
  • Loughlin, K
  • Smith, D
  • et al.

Published Web Location

http://jid.oxfordjournals.org/content/190/3/504.long
No data is associated with this publication.
Abstract

Background. High human T lymphotropic virus (HTLV)-I provirus load (VL) has been associated with an increased risk of HTLV-associated myelopathy, but little is known about variation in HTLV-I or -II VLs by demographic characteristics and risk behaviors. Methods. We measured HTLV-I and HTLV-II VLs in a large cohort of 127 HTLV-I-seropositive and 328 HTLV-II-seropositive former blood donors, by use of real-time polymerase chain reaction using tax primers. Multivariable linear regression was used to control for confounding by relevant covariates. Results. The mean VLs were 3.28 log10copies/106peripheral blood mononuclear cells (PBMCs) (range, 0.5-5.3 log10copies/106PBMCs) for HTLV-I and 2.60 log10copies/106PBMCs (range, 0.05-5.95 log10copies/106PBMCs) for HTLV-II (P < .0001). HTLV-II VLs were higher in those subjects with subtype A infection (mean, 2.82 log10copies/106PBMCs) than in those with subtype B infection (mean, 2.29 log10copies/106PBMCs) (P = .005). Higher HTLV-I VL was associated with previous receipt of a blood transfusion (P = .04), and lower HTLV-II VL was associated with female sex (P = .007). These associations persisted in virus-specific multivariate linear regression models controlling for potential confounding variables. Conclusions. VL was significantly higher in HTLV-I than in HTLV-II infection and was higher in HTLV-II subtype A than in HTLV-II subtype B infection. Chronic HTLV VLs may be related to the infectious dose acquired at the time of infection, with higher VLs following acquisition by blood transfusion and lower VLs following sexual acquisition.

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