Membrane fusion drives pronuclear meeting in the one-cell embryo.
Published Web Locationhttps://doi.org/10.1083/jcb.202001048
The mechanisms that control how the two parental pronuclei fuse in the first mitosis of the embryo are poorly understood. In this issue, Rahman et al. (2020. J. Cell Biol.https://doi.org/10.1083/jcb.201909137) found that membrane fusion between pronuclear envelopes, followed by fenestration, promotes pronuclear fusion.