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Synthesis of lipophilic 2-oxoamides based on gamma-aminobutyric and delta-aminovaleric analogues and their activity against phospholipase A2.

  • Author(s): Moutevelis-Minakakis, Panagiota
  • Neokosmidi, Afroditi
  • Filippakou, Maria
  • Stephens, Daren
  • Dennis, Edward A
  • Kokotos, George
  • et al.

Published Web Location

https://doi.org/10.1002/psc.889
No data is associated with this publication.
Abstract

A variety of lipophilic 2-oxoamides based on gamma-aminobutyric and delta-aminovaleric analogues were synthesized. 2-oxoamides containing a tetrazole, a thioethyl or a thioacetyl group are weak inhibitors of GIVA cPLA(2), while derivatives containing a methyl tetrazole, a diethyl phosphonate or a thioethyl group are weak inhibitors of GV sPLA(2).

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