Synthesis of lipophilic 2-oxoamides based on gamma-aminobutyric and delta-aminovaleric analogues and their activity against phospholipase A2.
- Author(s): Moutevelis-Minakakis, Panagiota;
- Neokosmidi, Afroditi;
- Filippakou, Maria;
- Stephens, Daren;
- Dennis, Edward A;
- Kokotos, George
- et al.
Published Web Locationhttps://doi.org/10.1002/psc.889
A variety of lipophilic 2-oxoamides based on gamma-aminobutyric and delta-aminovaleric analogues were synthesized. 2-oxoamides containing a tetrazole, a thioethyl or a thioacetyl group are weak inhibitors of GIVA cPLA(2), while derivatives containing a methyl tetrazole, a diethyl phosphonate or a thioethyl group are weak inhibitors of GV sPLA(2).