- Main
International stroke genetics consortium recommendations for studies of genetics of stroke outcome and recovery
- Lindgren, Arne G;
- Braun, Robynne G;
- Majersik, Jennifer Juhl;
- Clatworthy, Philip;
- Mainali, Shraddha;
- Derdeyn, Colin P;
- Maguire, Jane;
- Jern, Christina;
- Rosand, Jonathan;
- Cole, John W;
- Lee, Jin-Moo;
- Khatri, Pooja;
- Nyquist, Paul;
- Debette, Stéphanie;
- Wei, Loo Keat;
- Rundek, Tatjana;
- Leifer, Dana;
- Thijs, Vincent;
- Lemmens, Robin;
- Heitsch, Laura;
- Prasad, Kameshwar;
- Conde, Jordi Jimenez;
- Dichgans, Martin;
- Rost, Natalia S;
- Cramer, Steven C;
- Bernhardt, Julie;
- Worrall, Bradford B;
- Fernandez-Cadenas, Israel;
- Consortium, International Stroke Genetics
- et al.
Published Web Location
https://doi.org/10.1177/17474930211007288Abstract
Numerous biological mechanisms contribute to outcome after stroke, including brain injury, inflammation, and repair mechanisms. Clinical genetic studies have the potential to discover biological mechanisms affecting stroke recovery in humans and identify intervention targets. Large sample sizes are needed to detect commonly occurring genetic variations related to stroke brain injury and recovery. However, this usually requires combining data from multiple studies where consistent terminology, methodology, and data collection timelines are essential. Our group of expert stroke and rehabilitation clinicians and researchers with knowledge in genetics of stroke recovery here present recommendations for harmonizing phenotype data with focus on measures suitable for multicenter genetic studies of ischemic stroke brain injury and recovery. Our recommendations have been endorsed by the International Stroke Genetics Consortium.
Many UC-authored scholarly publications are freely available on this site because of the UC's open access policies. Let us know how this access is important for you.
Main Content
Enter the password to open this PDF file:
-
-
-
-
-
-
-
-
-
-
-
-
-
-