Skip to main content
eScholarship
Open Access Publications from the University of California

Early Chk1 Phosphorylation Is Driven by Temozolomide-Induced, DNA Double Strand Break- and Mismatch Repair-Independent DNA Damage

  • Author(s): Ronen, Sabrina
  • Pieper, Russell
  • Ito, M
  • Ohba, S
  • Gaensler, K
  • Ronen, SM
  • Mukherjee, J
  • Pieper, RO
  • et al.

Published Web Location

http://europepmc.org/articles/PMC3646831?pdf=render
No data is associated with this publication.
Abstract

Temozolomide (TMZ) is a DNA methylating agent used to treat brain cancer. TMZ-induced O6-methylguanine adducts, in the absence of repair by O6-methylguanine DNA methyltransferase (MGMT), mispair during DNA replication and trigger cycles of futile mismatch

Many UC-authored scholarly publications are freely available on this site because of the UC Academic Senate's Open Access Policy. Let us know how this access is important for you.

Item not freely available? Link broken?
Report a problem accessing this item