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Intracellular protein delivery employing FLuc nanocapsules as a probe

  • Author(s): ZHENG, WEIBIN
  • Advisor(s): Lu, Yunfeng
  • et al.
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Abstract

A novel protein delivery platform has been developed to efficiently deliver protein or enzyme by forming a thin polymer shell via free radical polymerization. The everlasting limitations for protein therapy are mainly poor stability and low permeability through biological barriers. The rational design of the nanocarriers based on the protein nanocapsule technology can endow nanoparticles with ideal size and reliable surface properties. In this thesis, the extent of the firefly luciferase encapsulation delivery system is further explored in the field of induced apoptosis by various drug treatments in cancer cells.

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This item is under embargo until June 29, 2023.