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Circadian waveform bifurcation, but not phase-shifting, leaves cued fear memory intact.

  • Author(s): Harrison, EM
  • Carmack, SA
  • Block, CL
  • Sun, J
  • Anagnostaras, SG
  • Gorman, MR
  • et al.
Abstract

In mammals, memory acquisition and retrieval can be affected by time of day, as well as by manipulations of the light/dark cycle. Under bifurcation, a manipulation of circadian waveform, two subjective days and nights are experimentally induced in rodents. We examined the effect of bifurcation on Pavlovian fear conditioning, a prominent model of learning and memory. Here we demonstrate that bifurcation of the circadian waveform produces a small deficit in acquisition, but not on retrieval of fear memory. In contrast, repeated phase-shifting in a simulated jet-lag protocol impairs retrieval of memory for cued fear. The results have implications for those attempting to adjust to shift-work or other challenging schedules.

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