In vitro membrane reconstitution of the T-cell receptor proximal signaling network
- Author(s): Vale, Ronald
- Hui, E
- Vale, RD
- et al.
Published Web Locationhttp://europepmc.org/articles/PMC4062301?pdf=render
T-cell receptor (TCR) phosphorylation is controlled by a complex network that includes Lck, a Src family kinase (SFK), the tyrosine phosphatase CD45 and the Lck-inhibitory kinase Csk. How these competing phosphorylation and dephosphorylation reactions are